SOCR logoBPAD

Cluster Stability Explorer

Resample the cohort repeatedly and measure how often the same subjects land together — the only honest test of a phenotype.

  • stability
  • bootstrap
  • adjusted Rand index
  • reproducibility
Mean off-diagonal consensus
0.345
SD off-diagonal
0.283
Stable pairs (>0.8)
8.7%
Unstable pairs (<0.2)
39.1%

Consensus matrix

Block-diagonal = stable; diffuse = unstable clustering.

Final cluster assignments (PCA space)

-2-1.5-1-0.500.511.522.53-2-10123PC1PC2

Mean silhouette width vs K

weakstrong1.522.533.544.555.500.10.20.30.40.50.60.7KMean silhouette width

No clear maximum implies no natural cluster count.

Reading the consensus matrix
Low consensus: cluster assignments are highly unstable. The data likely forms a continuum, not discrete subtypes.